Mathematical modeling of drug resistance due to KRAS mutation in colorectal cancer

[KRAS gene mutation in colorectal cancer].

BACKGROUND KRAS oncogene is involved in colorectal carcinogenesis in 22 to 45% of cases. AIM To determine the frequency, types and distribution of KRAS mutations in colorectal cancer. MATERIAL AND METHODS KRAS mutations studies were carried out in primary tumors and metastases of colo-rectal cancer from 56 women aged 60 ± 14 years and 53 men aged 61 ± 11 years. Formalin fixed and paraffin e...

Mathematical Modeling and Lyapunov-Based Drug Administration in Cancer Chemotherapy

In this paper a new mathematical model is developed for the dynamics between tumor cells, normal cells, immune cells, chemotherapy drug concentration and drug toxicity. Then, the theorem of Lyapunov stability is applied to design treatment strategies for drug protocols that ensure a desired rate of tumor cell kill and push the system to the area with smaller tumor cells. Using of this theorem a...

A Mathematical Model for Assessing KRAS Mutation Effect on Monoclonal Antibody Treatment of Colorectal Cancer

The most challenging task in colorectal cancer research nowadays is to understand the development of acquired resistance to antiEGFR drugs. The key reason for this problem is the KRAS mutations produced after the treatment with monoclonal antibodies (mAb). KRAS screening tests done before the start of the treatment are not very sensitive to identify minute quantity of the mutated cells, which c...

Prognostic and Predictive Roles of KRAS Mutation in Colorectal Cancer

The RAS gene family is among the most studied and best characterized of the known cancer-related genes. Of the three human ras isoforms, KRAS is the most frequently altered gene, with mutations occurring in 17%-25% of all cancers. In particular, approximately 30%-40% of colon cancers harbor a KRAS mutation. KRAS mutations in colon cancers have been associated with poorer survival and increased ...

KRAS, NRAS, and BRAF Mutation Analysis in Metastatic Colorectal Cancer